Author: zapati78

Marijuana helps reduce cancer tumors

According to research conducted by researchers at University of East Anglia in England, marijuana can be a compound capable of stopping the growth of cancer tumors.

The research was published in the Journal of Biological Chemistry, and reveals that THC (tetra hidrocarbo cannabinol), the main compound cannabis generates shrinkage of tumors with cancer.

According to Dr. Peter McCormick, this compound is known to act in a specific family of receptor cells, however, is still unknown how the THC that is responsible to have these effects in tumors.

The discoveries were made by injecting mice using THC two breast cancer cells. the effect of the substance is explained, however, is not known how it works in cells, so they know is far from knowing the precise effects.

On the other hand, it is necessary to study the dose to be applied, for an appropriate and effective reduction of the tumor in question. In addition, the substance did not work similarly in other tumors.

This is not the first time scientists discovered that marijuana is an effective substance to fight cancer. In previous research, they found that THC can halve a lung tumor, and also stop it spreading to other parts.

It has been revealed that the CBD (cannabidiol), another compound cannabis is a promising substance in the fight against cancer, since some studies failed to stop metastasis in many types of aggressive cancer.

Marijuana for medicinal uses is still under discussion around the world, especially in America, where the company pushes its legalization for therapeutic purposes. Remains to be seen, the way research can carve for its use is not punishable by law.

Marijuana for asthma

 

Although we are quite aware today about the bad habit of smoking, which can cause us serious illness and long-term consequences in terms of our lungs and affect other organs, marijuana stays out of most of the conclusions removed from snuff, and some studies have shown that it is a powerful asset to combat pulmonary system related diseases.

Although probably under pressure from governments and some lobbyists with interest, most of these studies concluded and no relevant findings, certain laboratory tests have shown that patients with respiratory problems that are given marijuana respond better than the who they are treated with other substances. In fact, cannabis has an innate component that causes the expansion of the bronchi, which can reduce discomfort for asthma and especially increase lung capacity of the patient.

Therapeutic Cannabis

Associations towards the use of cannabis for therapeutic purposes are clear that marijuana has many options for the treatment of diseases, and tests they perform in their own clubs in which the consumption of this plant is allowed despite be prohibited in most countries considered an illegal – drug, improvements are evident.

Probably the less striking result that smoking marijuana can be a positive way to the lungs. However, keep in mind that, unlike snuff, cannabis is a natural plant that it is not processed for consumption.

Finally, it should be noted that the few studies that have seen the light and have given approval to the use of cannabis in the treatment of asthma and other diseases such as COPD, have concluded that only works on one plant consumption. If mixed with snuff whole effects are lost, and also suffer serious respiratory consequences.

Marijuana use reduces dopamine in the brain

The dopamine  is a transmitter in the brain crucial for the movement, thought and memory; but, above all, we know as the “hormone of pleasure”. Now, a new study conducted by researchers at the Medical Center of Columbia University in New York (USA) has revealed that marijuana could compromise the dopamine system.

Previous studies have found that drugs considered more “forceful” like heroin and cocaine decreased dopamine release; but, until now, he had never associated this result to marijuana.

Most addictions  to drugs end up blunting the release of dopamine during the greater dependence. On this basis, the researchers wanted to know if marijuana was linked to similar to these effects. To do this, they had the participation of 11 adults between 21 and 40 years, large marijuana (smoked marijuana daily), and also with 12 adults who did not consume any substance.

Experts used the technique of positron emission tomography (PET) to track a molecule that binds to the dopamine receptors in the brain in order to measure the release of this neurotransmitter in the brain striatum and in other regions such as the thalamus, midbrain and globus pallidus.

During the weeklong experiment, participants were unable to use marijuana to prevent images would measure the effects of this substance. The results showed that compared with the control group, the striatum of volunteers taking marijuana had a lower level of release of dopamine; so did other regions. All of them had lower levels of dopamine, which is associated with inattention and problems in learning and working memory.

” We do not know whether the decrease in dopamine was a preexisting condition or results of cannabis. But the conclusion is that long – term, cannabis use may endanger the dopaminergic system, which could have a variety of negative effects on learning  and behavior , “says the leader of the work.

Marijuana: Five pluses scientifically supported

Approve or prohibit the use of marijuana should be one of the most controversial discussions in the Western world. Cannabis smokers claim that smoking is much more harmful, it is a myth that marijuana leads to hard drug addiction and that the traffic problem would be solved by legalizing the plant so that everyone can grow if desired.

Here are 5 points we discussed, some conducted by various universities and institutions that support some positive effects of marijuana:

  1. The marijuana smoke is less harmful than cigarette: Many disagree and even say they smoke a spliff is more toxic than the snuff, but the truth is that a marijuana smoker, could hardly smoking on par with a person who consumes two packs a day. Forty days is not a feat that many do. But if I must say that cannabis users tend to hold the smoke longer in the lungs.

According to a study by the University of California, San Francisco, USA, marijuana smokers have lung and respiratory functions much less damaged than ordinary consumers of snuff. Yale University conducted research in 2007 that showed that smoking marijuana has no relation, for example, with the development of pulmonary emphysema.

  1. Smoking cannabis does not exacerbate mental problems, the contrary: Violent episodes of people, or criminal behavior often associated with alcohol or drugs. But marijuana is rarely a trigger for these behaviors. It is very unlikely that a murderer or rapist has these baser instincts by smoking a joint. However, cocaine or a bottle of whiskey can stimulate more strongly mental problems or schizophrenia of a subject. This does not mean that a normal person go crazy just by consuming these substances.

The negative effects of marijuana on men and women with mental problems were discarded by scientists. Experts from these houses of study also noted that marijuana can soothe or relax some mental disorders.

  1. Legalizing marijuana could lower suicide rates: A study from the University of San Diego and Montana State University, US, found that in the process of legalization of marijuana suicide rates among Americans between 20 and 39 years of age dropped considerably.
  2. Car crashes the star mostly people who consumed alcohol or other drugs, and in a small percentage who smoked marijuana: According to research, the link marijuana and traffic accidents is almost nonexistent. Professionals exemplified, based on the statistics, the odds of having a car accident for consumption of marijuana were 1.06, against a 2.96 cocaine and 4.46 amphetamines.
  3. The cannabis has medicinal properties: It is no secret that thousands of people use marijuana to reduce their physical ailments. This natural pain reliever is much older than those who sell traditional pharmacies. Relieving sclerosis, arthritis and muscle contractions are the many specialties of marijuana.

It should be noted that there are many studies showing the negative effects of marijuana, but others also talk about the negatives, just googled can read before consuming or even before criticizing cannabis smokers.

Marijuana doubled in twelve years in the US. 

The estimated adult consumers of marijuana figure doubled in the US between 2001 and 2013, reaching 9.5% of the population. As is the case with alcohol, many individuals who consume become addicted. the attitude and social perception and the legal treatment to this drug you are changing. In fact, there are 23 states where medical use is regulated and allowed cannabis, and there are four states where recreational use is allowed.

The authors of the study, managed data on prevalence rates of cannabis use and rates of disorders among consumers United States. the prevalence of marijuana rose from 4.1% of the adult population in 2001 to 9.5% in 2013.

The increase was particularly pronounced among women and among blacks, Hispanics, and Southerners, and among individuals at the age of 45-64 years. The rate of dependence or addiction also increased from 1.5% to 2.9% in the same period. This means that 6.8 million Americans abuse of this substance. However, disorders associated with consumption fell 30% consumer (35.6% in 2001).

The study concludes that “while many citizens think that should end the ban on recreational use, this and other research suggests the need for caution and implement a public education about the potential risks of marijuana use, including the danger of falling in addiction, although, as with the  spirit , many individuals may use marijuana without becoming addicted. However, the high risk of resulting disorders (30%) indicates that we must find a balance between use in therapies medical and recreational use. “

Marijuana detoxification

Some believe that smoking marijuana is a harmless recreational activity (albeit illegal). But regular or overuse can affect performance at work and social relations when the consumer becomes dependent.

The person who decides to stop using this substance may notice that cannabis dependence cause withdrawal symptoms, such as other drugs. The body needs regular doses of marijuana when they stop receiving it, and enters the detoxification process. For consumers long time, through the detoxification period can be cumbersome and difficult.

Symptom

The withdrawal effects of marijuana are not as serious as those associated with harder drugs, including alcohol. But detoxification should be monitored and treated to prevent future addictions. Withdrawal symptoms include insomnia, restlessness, irritability, headache, anxiety, stomach pain and loss of appetite. These symptoms were evident in studies conducted at the Columbia University in New York and published in the journal Psychopharmacology in February 1999. The researchers suggested that withdrawal symptoms may be the reason that consumers continue using marijuana or return to before the detoxification process is completed.

Aggressiveness

The heavy marijuana users have shown aggressive behavior more often than infrequent consumers three to five days after starting the withdrawal, according to a study by McLean Hospital / Harvard Medical School in Belmont, Massachusetts. His behavior returned to normal when they were examined 28 days later, this was reported in Psychopharmacology in April 1999.

Treatment

Medication may be indicated during detoxification to relieve anxiety and restlessness, and to relax. Therapy with vitamins and minerals can be used to stimulate the immune system and replenish deficiencies caused by the drug. It is advisable to drink plenty of water to help dilute the toxins.

Permanence in the system

Marijuana is more likely that other drugs stay in your system for weeks and even months. For this reason, many consumers are concerned about their drug tests. This can be a big problem for people when they report that will be analyzed for drugs before entering a new job. It is a good idea for them to seek help and medical advice during the detoxification period.

Tests

Many products claim to produce quick and useful results detoxification in a bottle after a drug test. They may contain vitamins, minerals and herbal cleaners. But the instructions usually explain that you need to drink a lot of water with the product a few hours before the urine test. However, some experts say that water alone masks the ingredients of marijuana in urine.

Marijuana contains a substance that stimulates sexual appetite

Most biomedical literature states that cannabinoids and endocannabinoids have inhibitory effects on sexual behavior, but new discoveries come to throw this land.

Marijuana contains a substance that stimulates sexual appetite, but also regulates vital processes like sleep, hunger and pain relief.

“Most biomedical literature states that cannabinoids and endocannabinoids have inhibitory effects on sexual behavior (dimmed), but we found the opposite effect, the difference is in the dose,” said the researcher.

Anandamide is naturally produced from lipids (fatty substances) in the cell membrane. In the nervous system they have been discovered specific receptors for it, which are the same as those that external cannabinoids bind marijuana.

It is classified as endocannabinoid or internal cannabinoid, because their properties and effects are similar to those of compounds such as tetrahydrocannabinol (THC) in marijuana.

The finding could serve as an argument in favor of upward movement for this drug decriminalize therapeutic purposes, after US gains ground in order of prohibition.

At low doses, endocannabinoids compounds stimulate sexual behavior, but in high doses inhibit, the scientists said.

“By using marijuana for medical purposes have to be careful with the doses used to not exceed stimulants to the inhibitory effects, because one of the side effects that may occur (on consumers) would be sexual dysfunction,” he warned the expert.

The researcher said he has experienced in other studies with male rodents do not copulate, but resumed their sexual activity after administering an injection of anandamide.

The findings are derived from experiments on laboratory rats, but the researcher considers that some data could be applied in the study of sexual response in humans.

A curious fact is that anandamide may also be found in products like chocolate and could be considered an “aphrodisiac in power”, but only on a very precise definition of the term and in low doses. “For a long time it was considered that a compound aphrodisiac was awakened sexual arousal. Now the concept is broader because it also considers that a substance that promotes the sexual responses of erection or ejaculation, whose dysfunction has nothing to do with sexual desire, “said the academic.

According to their findings, all those substances that facilitate sexual response could be classified as an aphrodisiac. “If I anandamide at low doses promotes sexual behavior, could be considered an aphrodisiac in power at that dose range,” he explained.

Conditions that are alleviated by marijuana – Part 1

 

Every day scientific research indicating that cannabis can help treat various health problems arise efficiently. The natural interaction of this plant with our endocannabinoid system makes often, can complement and in some cases, replace traditional medicines, besides serving as reinforcement therapies to provide a better quality of life for patients.

Scientific evidence has also led many countries raised their prohibitionist policies on cannabis, putting on the table the medical, social and economic benefits it could bring to its citizens. To realize its true dimension, these are just ten examples of diseases that, according to studies, are favored by marijuana use:

  • The cannabis can activate the self-destruction of cancer cells

Possibly it is one of the greatest advances in the social impact of this disease. There are many scientists who are currently studying the ability of cannabis as therapy against cancer, but one of the pioneers is a team, who spent ten years using cannabinoids to deal with certain types of tumors. Led by Professor Guillermo Velasco, focus their efforts on analyzing the usefulness of these organic compounds.

And they have found that cannabinoids have an “anti – tumor” effect that acts in three ways: On the one hand, induce death of tumor cells because they operate on activating your metabolism aggressively. Furthermore, prevent blood vessels which enable sending nutrients between cancer cells and thus prevent the tumor becomes larger generated. And thirdly, decrease the ability of tumor cells to move and invade other tissues, thus blocking the process of metastasis.

 

Implications:

The most important thing is that the US authorities have already given credibility to this type of study. The National Institute on Drug Abuse (NIDA) ensures that marijuana has the ability to kill cancer cells; and a few months ago the website of the National Cancer Institute of the United States was updated to indicate that cannabinoids help kill cancer killing damaged cells in the body while protecting healthy. This change in the official information is a breakthrough, almost quite an achievement, for those who have been fighting so long for recognition, in a visible way, the benefits of cannabis against cancer.

 

  • The cannabis can help treat Alzheimer’s disease

Again are the pioneer’s professionals in this field. The researcher demonstrated that cannabinoids have anti-inflammatory properties, so they can reduce the process that causes swelling and protect neurons (when a person has Alzheimer’s, your brain swells, suffers “neuroinflammation”).

But beyond its neuroprotective property, use cannabinoids in the treatment of incipient Alzheimer’s disease can help alleviate other problems that often occur. Has, for example, vascular properties as vasodilators are compounds; and help reduce hypertension and cardiovascular disorders often suffering patients.

 

Implications:

The latest research published in the Journal of Alzheimer’s Disease   (US) even suggest that THC can reduce levels of a protein linked to symptoms and could stop their advance. However, so far only been tested in rats and mice. It does not work with humans.

To be human experience, should be involved clinical neurologists and so far they have not. And there’s a bigger problem: drug companies do not seem very interested. A big mistake given the health and social problem of a disease such as Alzheimer’s, where very little is reversed compared to, for example, cancer research.

Conditions that are alleviated by marijuana – Part 2

 

  • CBD extract can reduce seizures in children with epilepsy


For a couple of years ago we come to know the experiences of children with epilepsy and with the help of oil rich in CBD cannabis, notice great improvements. For Charlotte Figi it is best known, because it has helped to change medical marijuana laws in the United States. But it is not the only data show that cannabidiol could become an important tool for treating different types of epilepsy option.

In fact, he is about to jump into the market Epidiolex a marijuana extract produced by the pharmaceutical company GW Pharmaceuticals (the same which markets Sativex) and containing cannabidiol. According to tests after 3 months from the first taking this drug, the overall frequency of seizures is reduced, on average, 45% in all participants. Another 47% experienced a reduction of 50% or more in such crises and almost 10% remained free of seizures. The Dravet syndrome who had managed to reduce their seizures by 62%; of them, 13% was free. Likewise, those who suffered from Lennox-Gastaut syndrome reduced them by 71%. Only 10% of those who participated in the study noted adverse effects such as drowsiness, fatigue and diarrhea or had to discontinue treatment.

 

Implications:

Thanks to this kind of evidence, the American Academy of Pediatrics United States has taken a big step to accept medical marijuana as a medical alternative for treating children. The institution supports every medical record is reviewed and is an optional decide whether the patient really needs cannabis to improve their health.

Children with epilepsy, for example, suffer hundreds of daily seizures (even more than 200 or 300 in pathologies such as Dravet Syndrome) that prevent them from being normal children, smile, talk, eat and move. For many of these children, cannabis is practically their only hope.

 

  • The medicinal cannabis can reduce opiate addiction


USA currently suffering an epidemic of addiction to painkillers, mostly opiate-based, a very effective substance, but at the same time very addictive. Sales have quadrupled in recent years and 2 million Americans are now addicted to these prescription drugs, while 16,000 people die each year from overdoses.

Numerous investigations assure that medical cannabis is an effective and safe analgesic that helps those dependent on opiates that “detoxify”, as shown in this study led by Columbia University. Cannabis has a higher safety profile against most pain medications on the market; and side effects associated with their use are typically mild (headache, drowsiness and dry mouth). Opioid drugs have many more health risks and unpleasant side effects.

 

Implications:

At a time when this addiction is wreaking havoc in our society we have to find a practical solution to manage pain. The “good news” is that states where medical marijuana is legal have significantly lower rates of addiction to these drugs and overdose deaths have fallen by an average of 25%. In Switzerland, it is the state which distributes small dose of cannabis to treat their citizens hooked on heroin. And in Portugal, the number of overdoses has declined markedly since the decriminalization of drugs in 2001.

Conditions that are alleviated by marijuana – Part 3

  • Cannabis is able to slow the progression of multiple sclerosis


The question of whether marijuana should be used to treat this disease is complex, as there is uncertainty about its benefits in relation to its side effects. Multiple sclerosis patients suffer permanent muscle contraction, spasms, severe pain and difficulty sleeping. Drugs that have traditionally been used to treat these symptoms are not effective, so many have chosen to consume cannabis.

Already in 2012, a study revealed the positive effects of cannabis in a model of multiple sclerosis in mice, demonstrating an improvement in disease progression. And there are more jobs that provide a scientific basis for drug development in order to develop based on the modulation of the endocannabinoid system therapies.

 

Implications:

These studies were the germ of Sativex, an oral spray derived from cannabis which significantly improves spasticity in a proportion of people with multiple sclerosis who had been identified as likely to respond to therapy. Well-controlled, clinical trials help resolve the contradictory conclusions about the use of marijuana to treat symptoms of MS. Today Sativex cannabis is the drug most commonly used to treat spasticity: now available in 15 countries and approved in another 12, including the United States.

 

  • The cannabis can alleviate the chronic pain caused by fibromyalgia


Fibromyalgia is a chronic pain syndrome of unknown origin characterized by widespread musculoskeletal pain, fatigue and multiple tender points on the body. Some patients often use cannabis therapeutically to treat the symptoms; however, there are still few clinical trials to evaluate its effect.

What we do know is that cannabis sativa has about 400 different chemical molecules, of which about 60 have analgesic properties. Some experts have suggested that cannabinoids are applicable for the treatment of chronic pain such as fibromyalgia, and have theorized that the disease may be associated with a deficiency underlying clinical endocannabinoid system, which also plays an important role in migraine syndrome irritable bowel and a growing list of medical conditions.

 

Implications:

One of the most important studies evaluated the benefits associated with cannabis use in patients with fibromyalgia. Their conclusion was clear: “Patients who use cannabis not only helps relieve pain and almost all associated symptoms, but also no one reported worsening after consumption”.

Also in a recent online survey by the National Pain Foundation in the United States, which involved more than 1300 patients with fibromyalgia, the result appointed cannabis as the most effective for symptoms treatment, beating all drugs on prescription (Lyrica, Cymbalta and Savella). Morgan Freeman the actor said that medical with medicinal cannabis after a near-fatal car accident in 1997. Since then he has suffered from fibromyalgia on his left arm: “I have chronic pain and the only thing that relieves me is marijuana.”